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Randy Bruno

Professor of Neuroscience

  • Tutorial Fellow at St Peter’s College

In all mammals including humans, the cerebral cortex mediates the highest levels of cognition, from sensing our world, applying learned knowledge, making decisions, to executing movements. The long-term goal of my research program is to understand how this cognitive machinery is assembled from unique cortical cell types arranged in circuits with specific architectures. Many mental disorders are diseases of these cortical circuits. Evolution’s solutions to cognition are also adaptable to produce intelligent machines in research and medicine. I am working to uncover principles of cortical microcircuitry and computation by exploiting electrophysiology, cellular imaging, cellular manipulation, and computational modeling - all in the context of behaviour. We use the rodent whisker-barrel system for our experiments because mice - one of the world's most heavily used model organisms - rely predominantly on whisker-mediated touch to explore the world. My lab's current focus is to understand the computational and behavioural roles of the different cortical layers.