Since 2011 I have been exploring new ways to present sleep and circadian rhythm research to the public. I began by speaking at Cafe Scientifique groups around Oxfordshire and in the city, which lead to further invites to talk at similar events around the country. I am also a keen musician, and in 2013 I was invited to lecture at the Oxford May Music Festival (Hollywell Music Rooms) where I used live drums to help illustrate some of the concepts involved. More recently I have been involved in two quite different public science events, Science Slam (Old Fire Station, Oxford October 2013) and Bright Club (Jericho Tavern, Oxford, March 2014) – both sell-outs - where a short entertaining set is required from several scientists in one night.
In addition, I was selected as one of the scientists from over a hundred candidates to work with professional animators on new visual art pieces for the public. The project, entitled ‘Silent Signal’ has involved an R&D process and was awarded a Large Arts Award by The Wellcome Trust. I have been working with award-winning animator Ellie Land on a piece named ‘Sleepless’ that is inspired by the concepts of synchrony and desynchrony. The film was completed in 2016 and is currently being shown around the UK and Europe as part of art installations and animation festivals.
More info on Silent Signal see www.silentsignal.org
Associate Professor of Neuroscience
I completed a PhD at the MRC National Institute for Medical Research in 1999 where I studied the control of retroviral expression in the mouse genome. I then joined Professor Kay Davies' group in the MRC Functional Genomics Unit, Oxford, where I focused on studying gene function in the brain using mouse models. This included models of neurodegeneration as well as human behavioural disorders, such as schizophrenia. In February 2013 I was awarded a European Research Council Starting (Consolidator) Grant and have established my own independent group in the Department to study new mechanisms that protect against oxidative stress in neurons. I also held a Junior Research Fellowship at Lady Margaret Hall. I am currently an editor of The Journal of Biological Chemistry (JBC).
I continue to study the role of environmental factors, including sleep and circadian rhythms, in psychiatric and neurodevelopmental disease and often give public lectures on these subjects.
TLDc proteins: new players in the oxidative stress response and neurological disease.
Finelli MJ. and Oliver PL., (2017), Mamm Genome, 28, 395 - 406
Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Clayton EL. et al, (2017), Hum Mol Genet, 26, 873 - 887
Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.
Wobst HJ. et al, (2017), Sci Rep, 7
Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau-/- mice.
Vargas-Caballero M. et al, (2017), Front Neurosci, 11
Stereotypic wheel running decreases cortical activity in mice.
Fisher SP. et al, (2016), Nat Commun, 7