- Riley Group Research Group
BHF Professor of Regenerative Medicine & Chair of Development and Cell Biology
Paul Riley took up the Chair of Development and Cell Biology in the Department of Physiology, Anatomy and Genetics on 1st October 2011, having been awarded a British Heart Foundation Personal Chair of Regenerative Medicine to support this position. He is also director of a recently established BHF Oxbridge Centre for Regenerative Medicine. He was previously Professor of Molecular Cardiology at the UCL-Institute of Child Health, London, where he was a principal investigator within the Molecular Medicine Unit at UCL-ICH since 1999. Prior to this, he obtained his PhD at UCL (1992-1995) and completed post-doctoral fellowships at the Samuel Lunenfeld Research Institute, Toronto, Canada and the Weatherall Institute of Molecular Medicine, Oxford (1996-1999). In 2008, Professor Riley was awarded the Outstanding Achievement Award of the European Society of Cardiology (ESC) Council on Basic Sciences. The award recognises a landmark discovery in the field of basic cardiovascular science when his team found that Thymosin b4 could mobilise dormant cells from adult epicardium to form new blood vessels in the heart, a major step towards finding a DIY mechanism to repair injury following a heart attack. Currently Professor Riley's team are focusing on exploiting the full potential of activated epicardial cells towards regenerating adult heart and understanding the mechanisms of activation of this lineage to extrapolate to human patients suffering from cardiovascular disease.
Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.
Petchey LK. et al, (2014), Proc Natl Acad Sci U S A, 111, 9515 - 9520
Dynamic haematopoietic cell contribution to the developing and adult epicardium.
Balmer GM. et al, (2014), Nat Commun, 5
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing.
Evans MA. et al, (2013), Nat Commun, 4
Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.
Risebro CA. et al, (2012), Circ Res, 111, e19 - e31
De novo cardiomyocytes from within the activated adult heart after injury.
Smart N. et al, (2011), Nature, 474, 640 - 644
Calcium handling precedes cardiac differentiation to initiate the first heart beat
Riley PR. et al, (2016), eLife
Loss of endogenous thymosin β4 accelerates glomerular disease.
Vasilopoulou E. et al, (2016), Kidney Int
Anatomy and development of the cardiac lymphatic vasculature: Its role in injury and disease.
Norman S. and Riley PR., (2016), Clin Anat, 29, 305 - 315
Characterisation of the human embryonic and foetal epicardium during heart development.
Risebro CA. et al, (2015), Development, 142, 3630 - 3636
Cardiac lymphatics are heterogeneous in origin and respond to injury.
Klotz L. et al, (2015), Nature, 522, 62 - 67