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Oliver Stone

PhD


BHF CRE Intermediate Research Fellow

During embryonic development, dynamic interplay between cell growth, differentiation and morphogenesis establishes diverse specialized cell types with unique functions.  My research aims to understand how these developmental processes specify the array of heterogeneous cell subtypes found within the vertebrate vasculature. 

 

Following a PhD at the University of Bristol studying neovascularization of adult tissues with David Bates, I undertook postdoctoral training with Didier Stainier at the University of California, San Francisco and Max Planck Institute for Heart and Lung Research.  Using zebrafish and mouse models, I studied the contribution of metabolism to vascular growth and DNA methylation (Stone et al., Nature Comms, 2018) and identified the earliest known transcriptional regulator of endothelial/blood cell differentiation from mesoderm (Reischauer*, Stone* et al., Nature, 2016). 

 

With funding from the Oxford British Heart Foundation Centre of Research Excellence, I am currently investigating the impact of lineage history on the terminal fate and function of endothelial cells in blood and lymphatic vessels.  

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