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Contact information

Email
matthew.frise@dpag.ox.ac.uk

Telephone
01865 282357

ORCID
https://orcid.org/0000-0001-5575-2531

Research groups

Robbins Group

Matthew Frise

BM BCh, MRCP, FFICM, DPhil

Academic Visitor

Biography

I read medicine as an undergraduate at the University of Cambridge before moving to Oxford for my clinical studies, which I completed in 2004.

Towards the end of my postgraduate medical training I undertook a DPhil in Professor Robbins' group examining the role of iron deficiency in human hypoxia physiology.

I now work full time in the NHS as a Consultant in Acute Medicine and Intensive Care at the Royal Berkshire Hospital, and remain actively involved in research with a particular focus on iron homeostasis and cardiopulmonary pathophysiology.

Key publications

Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.

Lakhal-Littleton S. et al, (2019), Proc Natl Acad Sci U S A, 116, 13122 - 13130

Clinical iron deficiency disturbs normal human responses to hypoxia.

Frise MC. et al, (2016), J Clin Invest, 126, 2139 - 2150

How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure.

Digne-Malcolm H. et al, (2016), Front Physiol, 7

Iron, oxygen, and the pulmonary circulation.

Frise MC. and Robbins PA., (2015), J Appl Physiol (1985), 119, 1421 - 1431

Non-contact measurement of oxygen saturation with an RGB camera.

Guazzi AR. et al, (2015), Biomed Opt Express, 6, 3320 - 3338

cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH. et al, (2015), BMJ Open, 5

Recent publications

Differential effects of high-altitude exposure on markers of oxidative stress, antioxidant capacity, and iron profiles.

Rytz CL. et al, (2022), Am J Physiol Regul Integr Comp Physiol, 323, R445 - R456

Non-anemic iron deficiency predicts prolonged hospitalisation following surgical aortic valve replacement: a single-centre retrospective study.

Frise MC. et al, (2022), J Cardiothorac Surg, 17

Publisher Correction: Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.

Frise MC. et al, (2022), Sci Rep, 12

Intravenous iron to treat anaemia following critical care: a multicentre feasibility randomised trial.

Shah A. et al, (2022), Br J Anaesth, 128, 272 - 282

bnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.

Frise MC. et al, (2022), Sci Rep, 12

Sir George Johnson FRCP (1818-96), high blood pressure and the continuing altercation about its origins.

Dorrington KL. and Frise MC., (2021), Exp Physiol, 106, 1886 - 1896

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.

Arabi YM. et al, (2021), Intensive Care Med, 47, 867 - 886

Iron deficiency anaemia in pregnancy: A contemporary review.

Benson CS. et al, (2021), Obstet Med, 14, 67 - 76

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

RECOVERY Collaborative Group ., (2021), Lancet, 397, 2049 - 2059

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

RECOVERY Collaborative Group ., (2021), Lancet, 397, 1637 - 1645

Management of the critically ill obstetric patient

Frise MC. and Frise CJ., (2021), Obstetrics Gynaecology and Reproductive Medicine, 31, 137 - 143

Genetic mechanisms of critical illness in COVID-19.

Pairo-Castineira E. et al, (2021), Nature, 591, 92 - 98

zithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

RECOVERY Collaborative Group ., (2021), Lancet, 397, 605 - 612

Successful Use of Argatroban to Treat a Critically Ill Patient with Coagulopathy and Nephropathy Secondary to COVID-19.

Frise MC. et al, (2020), TH Open, 4, e400 - e402

Iron bioavailability and cardiopulmonary function during ascent to very high altitude.

Holdsworth DA. et al, (2020), Eur Respir J, 56

Cardiac arrest precipitated by succinylcholine in a patient with COVID-19. Comment on Br J Anaesth 2020; 125: e255-7.

Crockett DC. et al, (2020), Br J Anaesth, 125, e336 - e337

Ventilatory demand-capacity imbalance during incremental exercise in COPD: an in silico perspective.

Neder JA., (2020), Eur Respir J, 56

Intravenous iron and chronic obstructive pulmonary disease: a randomised controlled trial.

Santer P. et al, (2020), BMJ Open Respir Res, 7

Life-threatening hyperkalaemia after succinylcholine.

Strachan J. and Frise M., (2020), Lancet, 395

Lessons of the month 1: Learning from Harvey; improving blood-taking by pointing the needle in the right direction.

Dorrington KL. and Frise MC., (2019), Clin Med (Lond), 19, 514 - 518

Intravenous iron delivers a sustained (8-week) lowering of pulmonary artery pressure during exercise in healthy older humans.

Cheng H-Y. et al, (2019), Physiol Rep, 7

Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.

Lakhal-Littleton S. et al, (2019), Proc Natl Acad Sci U S A, 116, 13122 - 13130

Human hypoxic pulmonary vasoconstriction is unaltered by 8 h of preceding isocapnic hyperoxia.

Cheng H-Y. et al, (2017), Physiol Rep, 5

Work at high altitudes

Frise MC. et al, (2016), 477 - 494

Iron Availability and Outcomes in Critical Illness.

Talbot NP. et al, (2016), Crit Care Med, 44

Clinical iron deficiency disturbs normal human responses to hypoxia.

Frise MC. et al, (2016), J Clin Invest, 126, 2139 - 2150

ge, sex and arterial pressure: the kidney is essential.

Frise MC. and Dorrington KL., (2016), Exp Physiol, 101

How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure.

Digne-Malcolm H. et al, (2016), Front Physiol, 7

How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure

Digne-Malcolm H. et al, (2016), FRONTIERS IN PHYSIOLOGY, 7

Iron, oxygen, and the pulmonary circulation.

Frise MC. and Robbins PA., (2015), J Appl Physiol (1985), 119, 1421 - 1431

The pulmonary vasculature--lessons from Tibetans and from rare diseases of oxygen sensing.

Frise MC. and Robbins PA., (2015), Exp Physiol, 100, 1233 - 1241

Exaggerated pulmonary vascular response to acute hypoxia in older men.

Balanos GM. et al, (2015), Exp Physiol, 100, 1187 - 1198

Non-contact measurement of oxygen saturation with an RGB camera.

Guazzi AR. et al, (2015), Biomed Opt Express, 6, 3320 - 3338

cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH. et al, (2015), BMJ Open, 5

Output, pressure and shunt: misrepresentation of pulmonary haemodynamics.

Frise MC. and Dorrington KL., (2015), J Physiol, 593

Management of the critically-ill obstetric patient

Frise CJ. et al, (2015), Obstetrics, Gynaecology and Reproductive Medicine, 25, 188 - 194

The pulmonary vasculature - lessons from Tibetans and from rare diseases of oxygen sensing.

Frise MC. and Robbins PA., (2014), Exp Physiol

Management of the critically ill obstetric patient

Frise MC. et al, (2012), Obstetrics, Gynaecology and Reproductive Medicine, 22, 241 - 247

Management of the critically ill obstetric patient

Frise MC. et al, (2012), Obstetrics, Gynaecology and Reproductive Medicine

The effect of point mutations EF-hands on the conformation, stability, and calcium affinity of calmodulin.

Masino L. et al, (2000), BIOPHYSICAL JOURNAL, 78, 423A - 423A

More publications