- Mommersteeg Group Research Group
Associate Professor of Developmental and Regenerative Medicine
I obtained my PhD in 2009 from the University of Amsterdam, where I worked in the laboratories of Prof. Vincent Christoffels and Prof. Antoon Moorman on the development of the conduction system and venous pole of the mammalian heart. In 2010, I joined the laboratory of Prof. John Parnavelas at University College London (UCL) as a long-term EMBO fellow. At UCL, my work focused on deciphering the roles of the Slit-Robo signalling pathway during mammalian heart development. While at UCL, I set up a project researching heart regeneration in Mexican cavefish together with dr. Yoshiyuki Yamamoto, which was sponsored by the British Heart Foundation in 2012. Both my post-doctoral projects form the basis for my current research interests in investigating the molecular mechanisms underlying heart regeneration and development.
Slit-Robo signalling in heart development.
Zhao J. and Mommersteeg MTM., (2018), Cardiovasc Res
Loss of function inROBO1is associated with tetralogy of Fallot and septal defects.
Kruszka P. et al, (2017), J Med Genet, 54, 825 - 829
Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.
Mommersteeg MTM. et al, (2015), Cardiovasc Res, 106, 55 - 66
Robo1 modulates proliferation and neurogenesis in the developing neocortex.
Yeh ML. et al, (2014), J Neurosci, 34, 5717 - 5731
Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.
Mommersteeg MTM. et al, (2013), Circ Res, 112, 465 - 475