- Mommersteeg Group Research Group
Associate Professor of Developmental and Regenerative Medicine
I obtained my PhD in 2009 from the University of Amsterdam, where I worked in the laboratories of Prof. Vincent Christoffels and Prof. Antoon Moorman on the development of the conduction system and venous pole of the mammalian heart. In 2010, I joined the laboratory of Prof. John Parnavelas at University College London (UCL) as a long-term EMBO fellow. At UCL, my work focused on deciphering the roles of the Slit-Robo signalling pathway during mammalian heart development. While at UCL, I set up a project researching heart regeneration in Mexican cavefish together with dr. Yoshiyuki Yamamoto, which was sponsored by the British Heart Foundation in 2012. Both my post-doctoral projects form the basis for my current research interests in investigating the molecular mechanisms underlying heart regeneration and development.
Loss of function in ROBO1 is associated with tetralogy of Fallot and septal defects.
Kruszka P. et al, (2017), J Med Genet
Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.
Mommersteeg MT. et al, (2015), Cardiovasc Res, 106, 55 - 66
Robo1 modulates proliferation and neurogenesis in the developing neocortex.
Yeh ML. et al, (2014), J Neurosci, 34, 5717 - 5731
Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.
Mommersteeg MT. et al, (2013), Circ Res, 112, 465 - 475
The ambiguous role of NKX2-5 mutations in thyroid dysgenesis.
van Engelen K. et al, (2012), PLoS One, 7