Luana Campos Soares
My research involves understanding the mechanisms that regulate the maintenance of neural and glioma stem cell populations, specifically the cues that allow a switch from proliferation towards differentiation and tissue commitment. I am currently investigating the role of the protein lectin Galectin-3 in this process. Galectin-3 in expressed in the Subventricular zone (SVZ), a neurogenic niche in the brain, even during homeostasis. We hope to understand whether this protein can be targeted to combat the glioma stem cell pool, which impairs response to treatment.
I graduated from Universidade Estadual Paulista - UNESP in Brazil (2014) with a major in Biology. I then obtained my Masters in Oncology (2016) at A.C.Camargo Cancer Center working with pathways involved in glioma progression.
Galectin-3 in the SVZ
Al-Dalahmah O. et al, (2020), Stem Cells, 38, 1149 - 1158
Al-Dalahmah O. et al, (2020), Glia, 68, 435 - 450
Bardella C. et al, (2018), Prog Neurobiol, 170, 37 - 52
Souza RWA. et al, (2015), Am J Physiol Heart Circ Physiol, 309, H1629 - H1641