Websites
-
Sponsor: British Heart Foundation
Learning about silent genes that could help the heart repair itself
Joaquim Miguel Vieira
PhD
Academic Visitor
- Lecturer in Cardiovascular Medicine and BHF Research Fellow at King's College London
Joaquim Vieira studied Biochemistry as an undergraduate at the University of Lisbon, Portugal, and researched developmental angiogenesis for his PhD in Professor Christiana Ruhrberg's laboratory at University College London (UCL). After successful postdoctoral studies at UCL and University of Oxford with Professor Paul Riley investigating the epigenetic regulation of the epicardium and role of cardiac lymphatics during heart development and disease, he was awarded a British Heart Foundation (BHF) Intermediate Basic Science Research Fellowship to start his research group in Oxford.
The Vieira group studies the role of long noncoding RNAs and enhancers during epithelial-to-mesenchymal transition in the developing and diseased heart; and retains an interest in understanding cell-cell interactions in the developing heart supporting coronary and lymphatic vasculature expansion, as well as patterning of the cardiac autonomic system. A better understanding of the cellular and molecular mechanisms supporting organ development is poised to identify molecular targets to effect (adult) heart repair.
Dr Vieira is now an Academic Visitor at DPAG, visiting from King's College London where he is a Lecturer in Cardiovascular Medicine and BHF Research Fellow.
Previous University of Oxford College affiliations
October 2018 - September 2019: (non-stipendiary) Lecturer in Medicine at St. Hilda's College
October 2013 - October 2015: (non-stipendiary) Fulford Junior Research Fellow at Somerville College
Key publications
-
Selective requirements for NRP1 ligands during neurovascular patterning.
Journal article
Vieira JM. et al, (2007), Development, 134, 1833 - 1843
-
BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease.
Journal article
Vieira JM. et al, (2017), Nat Commun, 8
-
Cardiac lymphatics are heterogeneous in origin and respond to injury.
Journal article
Klotz L. et al, (2015), Nature, 522, 62 - 67
-
The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction.
Journal article
Vieira JM. et al, (2018), J Clin Invest, 128, 3402 - 3412
-
Characterisation of the human embryonic and foetal epicardium during heart development.
Journal article
Risebro CA. et al, (2015), Development, 142, 3630 - 3636
Recent publications
-
Quantitative Three-Dimensional Analysis of the Lymphatic Vasculature in the Postnatal Mouse Heart.
Journal article
Klaourakis K. et al, (2022), Methods Mol Biol, 2441, 171 - 181
-
Lymphatic clearance of immune cells in cardiovascular disease
Journal article
Ravaud C. et al, (2021), Cells, 10
-
VEGF Receptor Signalling in Vertebrate Development
Chapter
Vieira JM. et al, (2021), VEGF in Development, 14 - 29
-
The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development.
Journal article
Sun X. et al, (2021), Development, 148
-
The evolving cardiac lymphatic vasculature in development, repair and regeneration.
Journal article
Klaourakis K. et al, (2021), Nat Rev Cardiol
-
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart
Journal article
VIEIRA J. et al, (2021), Development
-
Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects.
Journal article
Kalisch-Smith JI. et al, (2021), Front Genet, 12