Contact information
Research groups
Collaborators
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Brent Ryan
Group Leader, Departmental Research Lecturer
James Lambton
PhD
Postdoctoral Research Scientist
I have joined the Wade-Martins lab as part of the Oxford-GSK IMCM looking at sporadic Parkinson’s disease. We aim to use iPSC derived dopaminergic neuron and co-cultures from sporadic patients with varying phenotypes to identify common disease mechanisms. Identification of common disease mechanisms in sporadic Parkinson’s should aide in novel therapeutic targets for patients with no identified genetic cause. I previously completed my PhD at Newcastle University where I focused congenital disorders of autophagy and the resulting neurological disease. This involved generating iPSC derived neural models of patients harbouring variants in core autophagy genes. Alongside my iPSC work, I characterised a number of novel autophagy related disease genes using a variety of patient tissues to better our understand cellular homeostasis in the absence of autophagy.