Heidi de Wet
Associate Professor of Physiology
- University Lecturer
Heidi de Wet received her Bachelor of Science degree from North Western University, South Africa, and was awarded a DPhil from the University of Cape Town (UCT) Medical School in 2000. She moved to the University of Oxford to pursue post-doctoral studies in 2003, where she joined the group of Professor Frances Ashcroft. Following two maternity breaks, she joined the Department of Physiology, Anatomy and Genetics as a University Lecturer in Physiology and Associate Professor. She is a Fellow and Director of Studies for Pre-clinical Medicine for St Catherine's College.
Her doctoral work in the Department of Chemical Pathology, UCT, first introduced her to the ATP-binding cassette (ABC) family of membrane transporters; these transporters have been the focus of her research ever since. Her post-doctoral research in Oxford focussed on neonatal diabetes, a rare form of type 2 diabetes, and the dysfunctional ABC transporters involved in this disease. More recently, her focus has shifted to studying the role of ABC transporters in gut endocrine K-and L-cells. These cells are involved in nutrient sensing in the small intestine and the subsequent secretion of appropriate peptide hormones that regulate several essential physiological responses to food intake.
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
Veprik A. et al, (2022), Commun Biol, 5
NMDA Receptor Antagonists Increase the Release of GLP-1 From Gut Endocrine Cells.
Cyranka M. et al, (2022), Front Pharmacol, 13
Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and GLP1 secretion and controls whole body glucose homeostasis
Veprik A. et al, (2019), DIABETOLOGIA, 62, S231 - S232
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
Cyranka M. et al, (2019), Obesity (Silver Spring), 27, 1292 - 1304
Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and glucagon-like peptide 1 (GLP-1) secretion and controls whole-body glucose homeostasis.
Veprik A. et al, (2019), DIABETIC MEDICINE, 36, 16 - 17