Heidi de Wet
Associate Professor of Physiology
Heidi de Wet received her Bachelor of Science degree from North Western University, South Africa, and was awarded a DPhil from the University of Cape Town (UCT) Medical School in 2000. She moved to the University of Oxford to pursue post-doctoral studies in 2003, where she joined the group of Professor Frances Ashcroft. Following two maternity breaks, she joined the Department of Physiology, Anatomy and Genetics as a University Lecturer in Physiology and Associate Professor. She is a Fellow and Director of Studies for Pre-clinical Medicine for St Catherine's College.
Her doctoral work in the Department of Chemical Pathology, UCT, first introduced her to the ATP-binding cassette (ABC) family of membrane transporters; these transporters have been the focus of her research ever since. Her post-doctoral research in Oxford focussed on neonatal diabetes, a rare form of type 2 diabetes, and the dysfunctional ABC transporters involved in this disease. More recently, her focus has shifted to studying the role of ABC transporters in gut endocrine K-and L-cells. These cells are involved in nutrient sensing in the small intestine and the subsequent secretion of appropriate peptide hormones that regulate several essential physiological responses to food intake.
Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides.
de Wet H. and Proks P., (2015), Biochem Soc Trans, 43, 901 - 907
Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.
Proks P. et al, (2014), J Gen Physiol, 144, 469 - 486
Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.
Proks P. et al, (2013), Diabetes, 62, 3909 - 3919
Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.
Fotinou C. et al, (2013), FEBS J, 280, 1051 - 1063
Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles
Fotinou C. et al, (2013), FEBS Journal, 280, 1051 - 1063