Heidi de Wet

• Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides.

  de Wet H. and Proks P., (2015), Biochem Soc Trans, 43, 901 - 907

• Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.

  Proks P. et al, (2014), J Gen Physiol, 144, 469 - 486

• Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

  Proks P. et al, (2013), Diabetes, 62, 3909 - 3919

• Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.

  Fotinou C. et al, (2013), FEBS J, 280, 1051 - 1063

• Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles

  Fotinou C. et al, (2013), FEBS Journal, 280, 1051 - 1063

• A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.

  de Wet H. et al, (2012), J Physiol, 590, 5025 - 5036

• A universally conserved residue in the SUR1 subunit of the K <inf>ATP</inf> channel is essential for translating nucleotide binding at SUR1 into channel opening

  de Wet H. et al, (2012), Journal of Physiology, 590, 5025 - 5036

• MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.

  Conradie MM. et al, (2011), Calcif Tissue Int, 89, 221 - 227

• Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.

  Proks P. et al, (2010), J Gen Physiol, 136, 389 - 405

• Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies.

  Pörksen S. et al, (2010), BMC Endocr Disord, 10

• The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids

  De Wet H. et al, (2010), FEBS Journal, 277, 2654 - 2662

• The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids.

  de Wet H. et al, (2010), FEBS J, 277, 2654 - 2662

• Asymmetric switching in a homodimeric ABC transporter: a simulation study.

  Aittoniemi J. et al, (2010), PLoS Comput Biol, 6

• Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

  Aittoniemi J. et al, (2009), Philos Trans R Soc Lond B Biol Sci, 364, 257 - 267

• SUR mutation in type 1 diabetes: autoimmunity prevents sulfonylurea rescue of diabetes caused by SUR1 mutation. Results from the Hvidore Study Group

  Porksen S. et al, (2008), DIABETOLOGIA, 51, S116 - S116

• A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.

  de Wet H. et al, (2008), EMBO Rep, 9, 648 - 654

• Analysing steroid modulation of BK(Ca) channels reconstituted into planar lipid bilayers.

  de Wet H. et al, (2008), Methods Mol Biol, 491, 177 - 186

• Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.

  Horsch K. et al, (2007), Mol Endocrinol, 21, 2929 - 2940

• Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.

  de Wet H. et al, (2007), Proc Natl Acad Sci U S A, 104, 18988 - 18992

• Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.

  Conradie MM. et al, (2007), J Endocrinol, 195, 229 - 240

• A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.

  Shimomura K. et al, (2007), Neurology, 69, 1342 - 1349

• Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

  Proks P. et al, (2007), Hum Mol Genet, 16, 2011 - 2019

• Studies of the ATPase activity of the ABC protein SUR1.

  de Wet H. et al, (2007), FEBS J, 274, 3532 - 3544

• Modulation of the BK channel by estrogens: examination at single channel level.

  De Wet H. et al, (2006), Mol Membr Biol, 23, 420 - 429

• The identification of transcriptional targets associated with osteoblast apoptosis signaling in response to growth factor withdrawal

  Liang M. et al, (2006), JOURNAL OF BONE AND MINERAL RESEARCH, 21, 1167 - 1167

• 3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

  Mikhailov MV. et al, (2005), EMBO J, 24, 4166 - 4175

• Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

  Horsch K. et al, (2004), JOURNAL OF BONE AND MINERAL RESEARCH, 19, 1030 - 1030

• Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

  Horsch K. et al, (2004), BONE, 34, S6 - S6

• Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.

  Engelbrecht Y. et al, (2003), Endocrinology, 144, 412 - 422

• Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

  Di Pietro A. et al, (2002), Cell Mol Life Sci, 59, 307 - 322

• Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding.

  de Wet H. et al, (2001), Biochemistry, 40, 10382 - 10391

• ATPase and Multidrug Transport Activities of the Overexpressed Yeast ABC Protein Yor1p

  Decottignies A. et al, (1998), Journal of Biological Chemistry, 273, 12612 - 12622

Recent Publications

• Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides.

  de Wet H. and Proks P., (2015), Biochem Soc Trans, 43, 901 - 907

• Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.

  Proks P. et al, (2014), J Gen Physiol, 144, 469 - 486

• Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

  Proks P. et al, (2013), Diabetes, 62, 3909 - 3919

• Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.

  Fotinou C. et al, (2013), FEBS J, 280, 1051 - 1063

• Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles

  Fotinou C. et al, (2013), FEBS Journal, 280, 1051 - 1063