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Denis Noble


Emeritus Professor of Cardiovascular Physiology

The integration of evolutionary biology with physiological science

Conversation with Mike Joyner at EB2015 in Boston, chaired by David Paterson


Denis Noble developed the first mathematical model of cardiac cells in 1960 using his discovery, with his supervisor Otto Hutter, of two of the main cardiac potassium ion channels. These discoveries were published in Nature (1960) and The Journal of Physiology (1962). The work was later developed with Dick Tsien, Dario DiFrancesco, Don Hilgemann and others to become the canonical models on which more than 100 cardiac cell models are based today. All are available on the CellML website

He was elected President of the International Union of Physiological Sciences (IUPS) at its Congress in Kyoto in 2009, and the opening speech is available as a pdf on this page. He was then elected for a second term at the 2013 Congress in Birmingham, UK. He also delivered the opening plenary lecture at the Congress (see Music of Life link) which is also published as an article in Experimental Physiology (2013). 

He is the author of the first popular book on Systems Biology, The Music of Lifeand his most recent lectures concern the implications for evolutionary biology. To follow the debate on this see the FAQ (Answers) pages on the Music of Life website. 

Denis Noble has published more than 500 papers and 11 books. 

What is Life?

Lecture at Karolinska Institute 2014

Key publications

Recent publications

More publications

Oxford Trobadors Concert

Hugely successful Concert recorded live to a full house in The Holywell Music Room on 23rd January 2016. Including popular favourites, Nadau ta Baptista, Arron d'Aimar, La Sestina, Immortela, Se Canta.........

Plenary lecture at IUPS 2013: Evolution and Physiology

Opening lecture at IUPS 2013 Congress in Birmingham: Evolution and physiology, a new synthesis

Music of Life lecture in Maribor, Slovenia

Featuring stories from The Music of Life