Research groups
Claudio Cortes Rodriguez
Postdoctoral Research Fellow
I am a Postdoctoral Research Fellow in Professor Paul Riley's group, interested in the cellular behaviours and mechanisms of heart development.
I goy my BSc from the University of Chile and then moved to Australia, where I obtained my PhD in Molecular Genetics and Development, studying rare genetic diseases (ciliopathies) as part of bench-to-bedside approaches. I then focused on heart development and moved to France for a postdoctoral position, where I specialised in developing new live imaging approaches to heart development in mice. I also focused on epithelial biology, Epithelial-to-mesenchymal transitions and how adhesion (cell-cell and the ECM) shapes development. As a side project, I also studied the role of Retinoic acid signaling in cardiac and skeletal muscle development.
I have now joined the Riley group to study human cardiac development as part of the Wellcome Trust Human Developmental Biology Initiative, imaging and mapping the cells that make up the human heart. I'm focusing on lineage-tracing and cell behaviour during compartmentalization of the heart. We have a growing number of collaborators for this, including the Srinivas group (DPAG) and the Rawlins group (Cambridge).
Recent publications
Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction.
Journal article
Sayers JR. et al, (2025), Nat Cardiovasc Res, 4, 163 - 179
Retinoic acid signalling regulates branchiomeric neck muscle development at the head/trunk interface.
Journal article
Dumas CE. et al, (2024), Development, 151
Protocols for Investigating the Epithelial Properties of Cardiac Progenitor Cells in the Mouse Embryo.
Chapter
Cortes C. et al, (2022), 2438, 231 - 250
EPySeg: a coding-free solution for automated segmentation of epithelia using deep learning.
Journal article
Aigouy B. et al, (2020), Development, 147
Tbx1 regulates extracellular matrix-cell interactions in the second heart field.
Journal article
Alfano D. et al, (2019), Hum Mol Genet, 28, 2295 - 2308

