- Ashley Group Research Group
Emeritus Professor of Physiology
Professor Chris Ashley, after doctoral work at the University of Bristol with Professor Peter Caldwell FRS, spent three years in the US as a Fulbright Travel Scholar, where he developed in 1967 with his colleague Ellis Ridgway, the novel aequorin luminescence method for measuring transient free calcium events in cells, pre-dating by some 10 years the development of calcium-sensitive fluorescent dyes to measure these intracellular phenomena. He returned to Bristol and was appointed to a University Lectureship in Physiology in 1970, and then to Oxford in 1976 as University Lecturer in Physiology and Medical Tutor at Corpus Christi College. He was awarded a DSc from the University of Oxford in 1987, elected an Hon MRCP by the Royal College of Physicians in 1998 and to a Fellowship of the Academy of Medical Sciences in 2002. He is Editor in Chief of the Journal of Muscle Research and Cell Motility, which he co-founded in 1980 with Richard Tregear.
Professor Andrew Fielding Huxley, OM, FRS, 1917-2012.
Ashley CC., (2012), J Muscle Res Cell Motil, 33
Synchronous in situ ATPase activity, mechanics, and Ca2+ sensitivity of human and porcine myocardium.
Griffiths PJ. et al, (2009), Biophys J, 97, 2503 - 2512
Laser flash photolysis of diazo-2, a caged calcium chelator: The relationship between the extent and rate of smooth muscle relaxation
Pelc R. et al, (2009), JOURNAL OF LASER APPLICATIONS, 21, 32 - 38
DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation.
Preston LC. et al, (2007), Biochem Biophys Res Commun, 360, 27 - 32
Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.
Robinson P. et al, (2007), FASEB J, 21, 896 - 905