- Carr Group Research Group
I have given talks about my work to BHF fund-raising groups and to local schools and was interviewed for the local press.
Associate Professor of Biomedical Science
I joined the department in 2003 and in my research I am investigating stem cell therapy for heart failure. I use high resolution magnetic resonance (MR) imaging to measure heart function and characterise the effect of cell therapy on the heart. Having shown that both cardiac progenitor cells isolated from heart tissue and induced pluripotent cells can improve heart function after myocardial infarction, my group is now looking at ways to optimise cell expansion in the lab and cell survival after transplantation.
I started life as a chemist, doing my undergraduate degree and my DPhil in Chemistry at the University of Oxford. I worked with MR spectroscopy and mass spectrometry both within the Chemistry Department here in Oxford and also in industry for Kodak Ltd and Synaptica Ltd. During my DPhil, I used MRS to study the conformation of small molecules in solution and as a post-doc I moved on to study the conformation of larger molecules such as peptides and proteins. Since joining the CMRG, I have been using MR imaging to measure heart function. I am now returning to using spectroscopy, to study metabolic changes in stem cells as they differentiate.
I had a career break to stay at home with my children and returned to science with a Daphne Jackson Fellowship which offers two year part-time research for returners to SET. Fellows carry out a supervised research project and a retraining programme at a UK University or research laboratory. This is an excellent scheme that I recommend to anyone on a career break and looking to return to science.
Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial.
Gomes RS. et al, (2013), ACS Nano, 7, 3362 - 3372
Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study.
Carr CA. et al, (2011), PLoS One, 6
Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat.
Carpenter L. et al, (2012), Stem Cells Dev, 21, 977 - 986
Murine cardiosphere-derived cells are impaired by age but not by cardiac dystrophic dysfunction.
Hsiao LC. et al, (2014), Stem Cells Dev, 23, 1027 - 1036
Chronic High-Fat Feeding Affects the Mesenchymal Cell Population Expanded From Adipose Tissue but Not Cardiac Atria.
Perbellini F. et al, (2015), Stem Cells Transl Med, 4, 1403 - 1414
The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.
Slingo M. et al, (2016), Am J Physiol Heart Circ Physiol, 311, H759 - H767
Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
Bruyneel AA. et al, (2016), J Cardiovasc Transl Res
On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.
Cole MA. et al, (2016), FASEB J, 30, 2684 - 2697
Abnormal cardiac energetics and metabolic profile in the Type 2 diabetic heart: a metabolomics approach
Fialho MDLS. et al, (2016), DIABETIC MEDICINE, 33, 81 - 81
Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.
Mansor LS. et al, (2016), J Physiol, 594, 307 - 320