- Carr Group Research Group
I have given talks about my work to BHF fund-raising groups and to local schools and was interviewed for the local press.
Associate Professor of Biomedical Science
I joined the department in 2003 and my research interests include cardiac physiology and metabolism and the use of endogenous cardiac stem cells to prevent heart failure. My research has shown that both endogenous cardiac progenitor cells and induced pluripotent stem cells significantly improve function of the heart after myocardial infarction. However, with both cell types, the improvement in function was not large and so we are now exploring tissue engineering solutions for cell delivery. We are also characterising changes in cell metabolism as the cells differentiate into beating cardiomyocytes, so that we can explore the use of these cells to detect metabolic side-effects of potential drug compounds.
I started life as a chemist, doing my undergraduate degree and my DPhil in Chemistry at the University of Oxford. I worked with MR spectroscopy and mass spectrometry both within the Chemistry Department here in Oxford and also in industry for Kodak Ltd and Synaptica Ltd. During my DPhil, I used MRS to study the conformation of small molecules in solution and as a post-doc I moved on to study the conformation of larger molecules such as peptides and proteins. Since joining the CMRG, I have been using MR imaging to measure heart function. I am now returning to using spectroscopy, to study metabolic changes in stem cells as they differentiate.
I had a career break to stay at home with my children and returned to science with a Daphne Jackson Fellowship which offers two year part-time research for returners to SET. Fellows carry out a supervised research project and a retraining programme at a UK University or research laboratory. This is an excellent scheme that I recommend to anyone on a career break and looking to return to science.
Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial.
Gomes RS. et al, (2013), ACS Nano, 7, 3362 - 3372
Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study.
Carr CA. et al, (2011), PLoS One, 6
Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat.
Carpenter L. et al, (2012), Stem Cells Dev, 21, 977 - 986
Murine cardiosphere-derived cells are impaired by age but not by cardiac dystrophic dysfunction.
Hsiao LC. et al, (2014), Stem Cells Dev, 23, 1027 - 1036
Chronic High-Fat Feeding Affects the Mesenchymal Cell Population Expanded From Adipose Tissue but Not Cardiac Atria.
Perbellini F. et al, (2015), Stem Cells Transl Med, 4, 1403 - 1414
Temporal accumulation and localization of isoflurane in the C57BL/6 mouse and assessment of its potential contamination in (19) F MRI with perfluoro-crown-ether-labeled cardiac progenitor cells at 9.4 Tesla.
Constantinides C. et al, (2017), J Magn Reson Imaging, 45, 1659 - 1667
Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation.
Mansor LS. et al, (2017), Cardiovasc Res, 113, 737 - 748
Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species.
Board M. et al, (2017), Int J Biochem Cell Biol, 88, 75 - 83
FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.
Surdo NC. et al, (2017), Nat Commun, 8
Ambiguity in the Presentation of Decellularized Tissue Composition: The Need for Standardized Approaches.
Bruyneel AA. and Carr CA., (2016), Artif Organs