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Anne Larsen

DPhil Student

I am interested in the role of microglia in neurodegenerative diseases, particularly how the endolysosomal system plays into the molecular pathology. My DPhil project is focused on investigating lysosomal dysfunction related to LRRK2, a protein that has been linked to sporadic and familial Parkinson’s disease. For this purpose, I use induced pluripotent stem cell (iPSC)-derived microglia to look for aberrant perturbations at an endogenous level. I have a BSc and MSc in Pharmaceutical Science from the University of Copenhagen where I graduated in 2020. During this time, I did structural biology research on the endogenous binding partner of GHB, CaMKIIa, in the Wellendorph lab at UCPH as well as the Kuriyan lab at University of California, Berkeley. In addition, I’ve recently returned from a PhD internship (RiSE) at Roche in Basel, Switzerland where I spent a year working in the Explorative Neurobiology research section.