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Research groups

Alex Demby

DPhil Student


Alex is intercalating his DPhil between his preclinical and clinical medicine studies. He completed his BA in Medical Sciences at the University of Oxford, including a dissertation on the influence of neuronal lineage on synaptic connectivity in cortex under the supervision of Professor Colin Akerman in the Department of Pharmacology.

Research Project

My research now focuses on how Gs-coupled GPCRs achieve specificity of response. cAMP is a ubiquitous second messenger, mediating signal transduction from a myriad of extracellular stimuli. I aim to understand how these receptors achieve specific responses via cAMP compartmentalisation within cardiac myocytes and cardiac fibroblasts.