Research groups
Colleges
Alexander Demby
MA (Oxon)
MB DPhil Student
I am studying a combined programme, integrating a BM BCh in Clinical Medicine with a DPhil in Physiology, Anatomy and Genetics.
I am now in the fourth year of my DPhil, working in the Zaccolo Group. My research focuses on signal transduction by G protein-coupled receptors (GPCRs). It is now well established that GPCRs achieve response specificity through compartmentalisation of intracellular signals. My project investigates how receptors coordinate this compartmentalisation in cardiac myocytes with a particular focus on the cAMP/PKA signalling pathway.
Recent publications
GPCR signalling: Yet another variant route in a highly complex road map.
Journal article
Demby A. and Zaccolo M., (2024), Cell Calcium, 124
The decision to randomise specialised foundation programme places must be revised, if not reversed.
Journal article
Pakunwanich N. et al, (2024), BMJ, 385
Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain.
Journal article
Buchan MJ. et al, (2024), Cell Rep, 43
Investigating G-protein coupled receptor signalling with light-emitting biosensors.
Journal article
Demby A. and Zaccolo M., (2023), Front Physiol, 14

