Postdoctoral Research Scientist
I am a Postdoctoral Research Scientist in Prof. Pawel Swietach’s group. Our research is investigating intracellular H+ ion control in cardiac hypertrophy and heart failure in a project funded by the British Heart Foundation. My research utilises confocal microscopy and live cell fluorescence imaging to quantify pathophysiological changes in cardiac cells at the functional level. as well as biochemical techniques to further explore protein alterations at the molecular level.
I completed my PhD in Prof. Rebecca Sitsapesan’s laboratory in the Department of Pharmacology at the University of Oxford. My PhD research focused on investigating how single-point mutations to the cardiac ryanodine receptor (RyR2), the main intracellular Ca2+ release channel in the heart, lead to life threatening arrhythmias. I am an expert in single-channel electrophysiology techniques to elucidate alterations to ligand sensitivity, gating kinetics, phosphorylation status and single-channel conductance of RyR2. This research was funded by a British Heart Foundation 4-Year PhD Studentship.
Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength.
Elbaz M. et al, (2019), Hum Mol Genet, 28, 2987 - 2999
Impaired Ligand Regulation of Native RyR2 Channels in the Catechol-aminergic Polymorphic Ventricular Tachycardia Mutation, RyR2-V2475F(+/-)
Wilson AD. et al, (2019), BIOPHYSICAL JOURNAL, 116, 381A - 381A
Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform.
Venturi E. et al, (2018), Br J Pharmacol, 175, 938 - 952
Atorvastatin Activates Skeletal RyR1 Channels: Towards Reducing Statin Side-Effects
Lindsay C. et al, (2018), BIOPHYSICAL JOURNAL, 114, 470A - 470A
Statins Bind to Cardiac Ryanodine Receptor (RyR2) Channels to Alter Opening Frequency
Wilson AD. et al, (2018), BIOPHYSICAL JOURNAL, 114, 621A - 622A