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We are recognised internationally for our pioneering approaches to systems biology and to computational modelling of the heart.
Cardiac Sciences

We are recognised internationally for our ...

We study everything from the structure of ion channels and transporters right up to their role in behaviour and human disease.
Cell Physiology

We study everything from the structure of ion ...

We dissect the molecular and cellular mechanisms underlying a range of developmental and reproductive processes.
Development & Cell Biology

We dissect the molecular and cellular mechanisms ...

We play a leading role in the development of more efficient and cost-effective sequencing technologies.
Functional Genomics

We play a leading role in the development of more ...

We use the full range of modern molecular genetic and imaging techniques to study a range of metabolic areas.
Metabolism & Endocrinology

We use the full range of modern molecular genetic ...

We host a number of internationally recognised neuroscience groups, with expertise in a wide range of experimental and computational methods.
Neuroscience

We host a number of internationally recognised ...

ATP-sensitive potassium (K-ATP) channels, insulin secretion and diabetes
Ashcroft Group

ATP-sensitive potassium (K-ATP) channels, insulin ...

Hearing Loss and Tinnitus
Bajo Lorenzana Group

Hearing Loss and Tinnitus

Cortical Microcircuitry in Behaviour
Bruno Group

Cortical Microcircuitry in Behaviour

Cellular mechanisms of oxygen and acid sensing in arterial chemoreceptors
Buckler Group

Cellular mechanisms of oxygen and acid sensing in ...

Optical probing of neural networks in the developing neocortex
Butt Group

Optical probing of neural networks in the ...

Optimising cardiac stem cell therapy by finding the best conditions for the cells in the lab and in the heart
Carr Group

Optimising cardiac stem cell therapy by finding ...

Glucocorticoids, Annexin 1 and the Neuroendocrine–Immune Interface
Christian Group

Glucocorticoids, Annexin 1 and the ...

Monoamine transmission: mechanisms, microcircuits and movement
Cragg Group

Monoamine transmission: mechanisms, microcircuits ...

Molecular Analysis of Neuromuscular Diseases
Davies Group

Molecular Analysis of Neuromuscular Diseases

Regulation of blood and lymphatic vessel development
De Val Group

Regulation of blood and lymphatic vessel ...

Role of ABC transporters in gut endocrine K-and L-cells
de Wet Group

Role of ABC transporters in gut endocrine K-and ...

We investigate neuroimmune molecular mechanisms underlying obesity.
Domingos Group

We investigate neuroimmune molecular mechanisms ...

Genetic Dissection of Sexual Behaviour
Goodwin Group

Genetic Dissection of Sexual Behaviour

Abnormal metabolism in type 2 diabetes, and how this affects the heart
Heather Group

Abnormal metabolism in type 2 diabetes, and how ...

Local neuromodulators of cardiac autonomic control
Herring Group

Local neuromodulators of cardiac autonomic control

Neural coding and plasticity in the auditory system
King Group

Neural coding and plasticity in the auditory ...

Spatial organization of fat metabolism.
Klemm Group

Spatial organization of fat metabolism.

Circuit Mechanisms of Learning and Decision Making
Lak Group

Circuit Mechanisms of Learning and Decision Making

Iron Homeostasis- Mechanisms and importance in systems (patho)physiology
Lakhal-Littleton Group

Iron Homeostasis- Mechanisms and importance in ...

Laboratory of Oscillations & Plasticity
Mann Group

Laboratory of Oscillations & Plasticity

Optical Control of Neurons;
Neuronal Control of Behaviour
Miesenboeck Group

Optical Control of Neurons; Neuronal Control of ...

Cerebral Cortical Development and Evolution
Molnar Group

Cerebral Cortical Development and Evolution

Heart regeneration & development
Mommersteeg Group

Heart regeneration & development

Intracellular calcium signalling in health and disease
Parekh Group

Intracellular calcium signalling in health and ...

Gene Transfer of Nitric Oxide Synthase into Cardiac Nerves Modulates Neurotransmission
Paterson Group

Gene Transfer of Nitric Oxide Synthase into ...

Neural activity in learning and executing movement
Peters Group

Neural activity in learning and executing movement

Human systems physiology: Respiratory, cardiovascular and metabolic function in response to stresses such as exercise and hypoxia
Robbins Group

Human systems physiology: Respiratory, ...

Cardio-immuno genomics
Simões Group

Cardio-immuno genomics

Development, homeostasis and regeneration of the cardiovascular system
Smart Group

Development, homeostasis and regeneration of the ...

Investigating the Genetic and Environmental Causes of Congenital Heart Disease
Sparrow Group

Investigating the Genetic and Environmental ...

Patterning and morphogenesis of the early mammalian embryo
Srinivas Group

Patterning and morphogenesis of the early ...

Spatiotemporal dissection of vascular heterogeneity
Stone Group

Spatiotemporal dissection of vascular ...

Acid handling and signalling in the heart and in cancer
Swietach Group

Acid handling and signalling in the heart and in ...

We study postnatal and adult mammalian brain stem cells to uncover fundamental developmental mechanisms and disease pathogenesis.
Szele Group

We study postnatal and adult mammalian brain stem ...

Translational cardiorespiratory physiology, with a focus on hypoxia and iron.
Talbot Group

Translational cardiorespiratory physiology, with ...

Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy
Tyler Group

Development and Application of Cardiac Magnetic ...

Investigating regulatory mechanisms of cardiac development, repair and regeneration.
Vieira Group

Investigating regulatory mechanisms of cardiac ...

Sleep, brain and behaviour laboratory
Vyazovskiy Group

Sleep, brain and behaviour laboratory

Memory, motivation and individuality
Waddell Group

Memory, motivation and individuality

Understanding molecular mechanisms of age-related neurodegenerative diseases to generate novel molecular therapies
Wade-Martins Group

Understanding molecular mechanisms of age-related ...

We investigate how the activity of neurons in the brain give rise to our perception of sound.
Walker Group

We investigate how the activity of neurons in the ...

Membrane transport in cartilage and cancer cells
Wilkins Group

Membrane transport in cartilage and cancer cells

Exosomes, Microcarriers and Regulated Secretion: Complex Forms of Inter-Cellular and Inter-Organism Communication
Wilson Group

Exosomes, Microcarriers and Regulated Secretion: ...

Cyclic Nucleotides signalling
Zaccolo Group

Cyclic Nucleotides signalling

Jeol 1010 Transmission Electron Microscope (TEM) allowing 2D imaging of specimen ultrastructure at up to 100,000x magnification.
Electron Microscopy

Jeol 1010 Transmission Electron Microscope (TEM) ...

Specialising in Cryosectioning, Immunohistochemistry and Light microscopy histological techniques.
Histology

Specialising in Cryosectioning, ...

Well equipped and versatile Media Services Unit in the Le Gros Clark Building. Services available to the wider University and external organisations.​
Media Services

Well equipped and versatile Media Services Unit ...

Two high resolution Magnetic resonance imaging systems, specialising in in vivo cine and cardiac MRI. We also have access to Hyperpolarized magnetic resonance imaging capabilities.
Preclinical Imaging Facilities

Two high resolution Magnetic resonance imaging ...

Latest news

Key cause of type 2 diabetes uncovered

Research led by Dr Elizabeth Haythorne and Professor Frances Ashcroft reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes. They have discovered that glucose metabolites, rather than glucose itself, are key to the progression of type 2 diabetes. Glucose metabolites damage pancreatic beta-cell function, so they are unable to release enough of the hormone insulin. Reducing the rate at which glucose is metabolised, and these glucose metabolites build up, can prevent the effects of hyperglycaemia.

New study shows clinical symptoms for Alzheimer’s can be predicted in preclinical models

Establishing preclinical models of Alzheimer’s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer’s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.

Updating the circuit maps of the sympathetic neural network

A new review from Professor Ana Domingos’ lab and colleagues offers a fresh modern viewpoint on sympathetic neurons and their relation to immune cells and obesity.