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We are recognised internationally for our pioneering approaches to systems biology and to computational modelling of the heart.

© The developing fish heart (Mathilda Mommersteeg)

Understanding heart disease using experimentation and computational physiology

Annual Burdon Sanderson Cardiac Science Lecture: to be given by Professor Christine Mummery, Leiden University Medical Centre, on Monday 14th October 2019.

 

The mission is to innovate and develop avenues of basic research using multi-scale experimental and computational techniques (from molecule to myocardium). The Burdon Sanderson Cardiac Science Centre is uniquely placed in Oxford to do this, because of its onsite linking of experimentation with integrative modelling. The centre is also a key component of Oxford’s BHF funded Centre of Research Excellence.

The challenge is to re-assemble the vast array of experimental data emerging over different spatial and temporal domains. The opportunity is provided by massively enhanced computing power, enhanced visualisation systems, guided by innovative and ground-breaking experimental work.

The aspiration is to exploit the predictive power of integrative biology, to tackle major issues in cardiac medicine (eg arrhythmia, cardiac hypertrophy, heart failure, regenerative medicine and repair).

The key to success is the close interplay between teams of experimentalists and computational biologists that underpin and complement the disease-led programmes of research within Clinical Departments of the Medical Sciences Division. Importantly this theme maps onto ion channels & signalling, developmental biology, genomics and metabolism which all cut across Cardiac Science.



Groups within this theme

Cellular mechanisms of oxygen and acid sensing in arterial chemoreceptors
Buckler Group

Cellular mechanisms of oxygen and acid sensing in ...

Optimising cardiac stem cell therapy by finding the best conditions for the cells in the lab and in the heart
Carr Group

Optimising cardiac stem cell therapy by finding ...

Ketone metabolism in exercise and disease
Clarke Group

Ketone metabolism in exercise and disease

Regulation of blood and lymphatic vessel development
De Val Group

Regulation of blood and lymphatic vessel ...

Role of triacylglycerol-rich lipoproteins in substrate supply and metabolic signalling
Evans Group

Role of triacylglycerol-rich lipoproteins in ...

Abnormal metabolism in type 2 diabetes, and how this affects the heart
Heather Group

Abnormal metabolism in type 2 diabetes, and how ...

Local neuromodulators of cardiac autonomic control
Herring Group

Local neuromodulators of cardiac autonomic control

Iron Homeostasis- Mechanisms and importance in systems (patho)physiology
Lakhal-Littleton Group

Iron Homeostasis- Mechanisms and importance in ...

The aim of our work is to determine the cellular mechanisms underlying the benefits of traditional multi-herbal Chinese medicines.
Ma Group

The aim of our work is to determine the cellular ...

Heart regeneration & development
Mommersteeg Group

Heart regeneration & development

Intracellular calcium signalling in health and disease
Parekh Group

Intracellular calcium signalling in health and ...

Gene Transfer of Nitric Oxide Synthase into Cardiac Nerves Modulates Neurotransmission
Paterson Group

Gene Transfer of Nitric Oxide Synthase into ...

Human systems physiology: Respiratory, cardiovascular and metabolic function in response to stresses such as exercise and hypoxia
Robbins Group

Human systems physiology: Respiratory, ...

Development, homeostasis and regeneration of the cardiovascular system
Smart Group

Development, homeostasis and regeneration of the ...

Investigating the Genetic and Environmental Causes of Congenital Heart Disease
Sparrow Group

Investigating the Genetic and Environmental ...

Acid handling and signalling in the heart and in cancer
Swietach Group

Acid handling and signalling in the heart and in ...

Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy
Tyler Group

Development and Application of Cardiac Magnetic ...

Cyclic Nucleotides signalling
Zaccolo Group

Cyclic Nucleotides signalling

Latest news

New human heart model set to boost future cardiac research and therapies

DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.

New target identified for repairing the heart after heart attack

An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. The Riley Group study was funded by the British Heart Foundation and led by BHF CRE Intermediate Transition Research Fellow Dr Filipa Simões.

New insights into how the brain makes sense of our constantly changing soundscape

We experience a wide range of sounds at varying levels. The brain's auditory neurons constantly adapt their responses to changes in sound level to help us perceive and understand what we hear. King Group researchers have previously demonstrated how these neurons do this and have now produced new evidence for exactly where this happens in the brain and the perceptual consequences of these adaptations.