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Publications

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation.

Do QB. et al, (2024), NPJ Parkinsons Dis, 10

Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease.

Kilfeather P. et al, (2024), Cell Rep, 43

Tau depletion in human neurons mitigates Aβ-driven toxicity.

Ng B. et al, (2024), Mol Psychiatry

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.

Hasan S. et al, (2023), Mol Neurodegener, 18

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.

Brimblecombe KR. et al, (2023), Eur J Neurosci

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.

Vahsen BF. et al, (2023), Nat Commun, 14

Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application

Maheshwari S. et al, (2023), Translational Neurodegeneration, 12

Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.

Williamson MG. et al, (2023), Hum Mol Genet, 32, 2808 - 2821

Impaired dopamine release in Parkinson's disease.

Cramb KML. et al, (2023), Brain, 146, 3117 - 3132

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.

Beccano-Kelly DA. et al, (2023), iScience, 26

Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.

Bogetofte H. et al, (2023), Cell Rep, 42

Early striatal hyperexcitability in anin vitrohuman striatal microcircuit model carrying the Parkinson’sGBA-N370Smutation

Do QB. et al, (2023)

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.

Carling PJ. et al, (2023), Autophagy, 19, 692 - 705

Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid.

Winchester L. et al, (2023), Brain Commun, 5

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.

Fdez E. et al, (2022), iScience, 25

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

Burley S. et al, (2022), Sci Rep, 12

Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.

Ng B. et al, (2022), Brain Commun, 4

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.

Ng J. et al, (2021), Sci Transl Med, 13

REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.

Ryan BJ. et al, (2021), J Neurosci, 41, 3731 - 3746

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.

Bengoa-Vergniory N. et al, (2021), Acta Neuropathol Commun, 9

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