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Publications

Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart.

da Luz Sousa Fialho M. et al, (2021), Diabetes

Rapid, B 1 -insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux.

Miller JJ. et al, (2021), Magn Reson Med, 85, 2978 - 2991

Peritransplant Cardiometabolic and Mitochondrial Function: The Missing Piece in Donor Heart Dysfunction and Graft Failure.

Wells MA. et al, (2021), Transplantation, 105, 496 - 508

Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart.

Savic D. et al, (2021), NMR Biomed

Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.

Timm KN. et al, (2020), Commun Biol, 3

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus.

Faulkner A. et al, (2020), Diabetologia, 63, 2205 - 2217

Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol.

Kerr M. et al, (2020), JCI Insight, 5

Positioning Metabolism as a Central Player in the Diabetic Heart.

Mereweather LJ. et al, (2020), J Lipid Atheroscler, 9, 92 - 109

Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized 13 C magnetic resonance spectroscopy.

Le Page LM. et al, (2019), NMR Biomed, 32

Human metabolism: pathways and clinical aspects

Evans RD. and Heather LC., (2019), Surgery (United Kingdom), 37, 302 - 309

The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity.

Sirey TM. et al, (2019), Elife, 8

Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease.

Sousa Fialho MDL. et al, (2019), Biochim Biophys Acta Mol Basis Dis, 1865, 831 - 843

Bernard and Joan Marshall Awards at the autumn meeting of the British Society for Cardiovascular Research 2017.

Carr CA. et al, (2018), Heart, 104, 1383 - 1384

Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes.

Dodd MS. et al, (2018), JACC Basic Transl Sci, 3, 485 - 498

The 'Goldilocks zone' of fatty acid metabolism; to ensure that the relationship with cardiac function is just right.

Kerr M. et al, (2017), Clin Sci (Lond), 131, 2079 - 2094

Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation.

Mansor LS. et al, (2017), Cardiovasc Res, 113, 737 - 748

THE CARDIAC HEPCIDIN/FERROPORTIN AXIS IS ESSNTIAL FOR CARDIAC IRON HOMEOSTASIS AND FUNCTION

Lakhal-Littleton S. et al, (2017), HEART, 103, A137 - A137

Mitochondrial Dysfunction Is a Common Feature of Injury in Donor Kidneys After Brain and Circulatory Death

Lo Faro M. et al, (2017), AMERICAN JOURNAL OF TRANSPLANTATION, 17, 727 - 728

Targeting hypoxia-inducible factor 1 (HIF-1) signalling in the Type 2 diabetic heart: dimethyloxaloylglycine (DMOG) improves functional recovery following ischaemia-reperfusion despite no change in glycolysis

Sousa Fialho MDL. et al, (2017), DIABETIC MEDICINE, 34, 49 - 49

Temporal effects of streptozotocin (STZ) induced diabetes on cardiac metabolism and function using hyperpolarised C-13 MRS and CINE MRI

Savic DS. et al, (2017), DIABETIC MEDICINE, 34, 50 - 50

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