Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.
Hill TG. et al, (2024), Nat Metab
KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts.
Burkart M-E. et al, (2024), Brain
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life.
Vedovato N. et al, (2024), Diabetologia, 67, 940 - 951
KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture
Ashcroft FM., (2023), Diabetes, 72, 693 - 702
Glucokinase activity in diabetes: too much of a good thing?
Ashcroft FM. et al, (2022), Trends Endocrinol Metab
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
Haythorne E. et al, (2022), Nat Commun, 13
The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel.
Pipatpolkai T. et al, (2022), J Physiol
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate.
Koberstein JN. et al, (2022), Proc Natl Acad Sci U S A, 119
Dissection-independent production of Plasmodium sporozoites from whole mosquitoes.
Blight J. et al, (2021), Life Sci Alliance, 4
Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time.
Usher SG. et al, (2021), J Vis Exp
The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.
Sachse G. et al, (2021), Diabetes
Metabolic regulation of insulin secretion in health and disease
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Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease
Pipatpolkai T. et al, (2020), Communications Chemistry, 3
New insights into KATP channel gene mutations and neonatal diabetes mellitus.
Pipatpolkai T. et al, (2020), Nat Rev Endocrinol, 16, 378 - 393
Dissection-independent production of a protective whole-sporozoite malaria vaccine
Blight J. et al, (2020)
Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.
Usher SG. et al, (2020), Elife, 9
Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice.
Sachse G. et al, (2020), Wellcome Open Res, 5
Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice
Sachse G. et al, (2020), Wellcome Open Research, 5, 1 - 17
Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.
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