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Publications

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.

Hill TG. et al, (2024), Nat Metab

KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts.

Burkart M-E. et al, (2024), Brain

A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life.

Vedovato N. et al, (2024), Diabetologia, 67, 940 - 951

KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture

Ashcroft FM., (2023), Diabetes, 72, 693 - 702

Glucokinase activity in diabetes: too much of a good thing?

Ashcroft FM. et al, (2022), Trends Endocrinol Metab

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.

Haythorne E. et al, (2022), Nat Commun, 13

The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel.

Pipatpolkai T. et al, (2022), J Physiol

Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate.

Koberstein JN. et al, (2022), Proc Natl Acad Sci U S A, 119

Dissection-independent production of Plasmodium sporozoites from whole mosquitoes.

Blight J. et al, (2021), Life Sci Alliance, 4

Voices: Insulin and beyond

Roth J. et al, (2021), Cell Metabolism, 33, 692 - 699

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time.

Usher SG. et al, (2021), J Vis Exp

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.

Sachse G. et al, (2021), Diabetes

Metabolic regulation of insulin secretion in health and disease

Haythorne E. and Ashcroft FM., (2021), Biochemist, 43, 4 - 8

Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease

Pipatpolkai T. et al, (2020), Communications Chemistry, 3

New insights into KATP channel gene mutations and neonatal diabetes mellitus.

Pipatpolkai T. et al, (2020), Nat Rev Endocrinol, 16, 378 - 393

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.

Usher SG. et al, (2020), Elife, 9

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice.

Sachse G. et al, (2020), Wellcome Open Res, 5

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice

Sachse G. et al, (2020), Wellcome Open Research, 5, 1 - 17

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.

Ved N. et al, (2019), Lab Anim, 53, 630 - 633

Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333-3335.

Myngheer N. et al, (2019), Diabetes Care, 42

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