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Publications

PTCH1mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesis

van Essen MJ. et al, (2023)

Purkinje Cell Patterning-Insights from Single-Cell Sequencing.

Apsley EJ. and Becker EBE., (2022), Cells, 11

Cerebellar Modelling Using Human Induced Pluripotent Stem Cells

van Essen MJ. et al, (2022), Neuromethods, 177, 1 - 21

High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids

Nayler S. et al, (2021), Scientific Reports, 11

Moonwalker Mouse

Becker EBE., (2021), Handbook of the Cerebellum and Cerebellar Disorders: Second Edition: Volume 3, 1773 - 1788

Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.

Argent L. et al, (2020), J Biol Chem, 295, 12716 - 12726

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development

Nayler S. et al, (2020)

Deconstructing cerebellar development cell by cell

Van Essen M. et al, (2020), PLoS Genetics

Deconstructing cerebellar development cell by cell.

van Essen MJ. et al, (2020), PLoS Genet, 16

TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells.

Wu B. et al, (2019), Elife, 8

A gene expression signature in developing Purkinje cells predicts autism and intellectual disability co-morbidity status.

Clifford H. et al, (2019), Sci Rep, 9

TRPC3 is essential for functional heterogeneity of cerebellar Purkinje cells

Wu B. et al, (2018)

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Wong MMK. et al, (2018), Acta Neuropathol Commun, 6

A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.

Watson LM. et al, (2018), Cerebellum, 17, 419 - 427

Genotype-phenotype correlations, dystonia and disease progression in spinocerebellar ataxia type 14.

Chelban V. et al, (2018), Mov Disord, 33, 1119 - 1129

Cerebellar involvement in autism and ADHD.

Bruchhage MMK. et al, (2018), 155, 61 - 72

The Use of Stem Cell-Derived Neurons for Understanding Development and Disease of the Cerebellum.

Nayler SP. and Becker EBE., (2018), Front Neurosci, 12

From Mice to Men: TRPC3 in Cerebellar Ataxia.

Becker EBE., (2017), Cerebellum, 16, 877 - 879

Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.

Watson LM. et al, (2017), Am J Hum Genet, 101

Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.

Watson LM. et al, (2017), Am J Hum Genet, 101

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