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Metabolic regulation of insulin secretion in health and disease

Journal article

Haythorne E. and Ashcroft FM., (2021), Biochemist, 43, 4 - 8

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice.

Journal article

Sachse G. et al, (2020), Wellcome Open Res, 5

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice

Journal article

Sachse G. et al, (2020), Wellcome Open Research, 5, 1 - 17

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Journal article

Haythorne E. et al, (2019), Nat Commun, 10

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Journal article

Knudsen JG. et al, (2019), Cell Metab, 29, 430 - 442.e4

Chronic d-serine supplementation impairs insulin secretion.

Journal article

Suwandhi L. et al, (2018), Mol Metab, 16, 191 - 202

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

Journal article

Proks P. et al, (2018), PLoS One, 13

Local and regional control of calcium dynamics in the pancreatic islet.

Journal article

Rutter GA. et al, (2017), Diabetes Obes Metab, 19 Suppl 1, 30 - 41

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons.

Journal article

Haythorne E. et al, (2016), Neuropharmacology, 111, 212 - 222

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Journal article

Johnston NR. et al, (2016), Cell Metab, 24, 389 - 401

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

Journal article

Martinez-Sanchez A. et al, (2016), Diabetes, 65, 1268 - 1282

Disallowance of acyl-CoA thioesterase 7 (Acot7) in beta cells is required for normal insulin secretion and glucose tolerance

Conference paper

Martinez-Sanchez A. et al, (2016), DIABETIC MEDICINE, 33, 38 - 38

Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour.

Journal article

Beall C. et al, (2012), Diabetologia, 55, 2432 - 2444