Protocol for separating cancer cell subpopulations by metabolic activity using flow cytometry.
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Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
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Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells.
Blaszczak W. et al, (2023), Cell Rep, 43
What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?
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Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2.
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