Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.
Deen SS., Riemer F., McLean MA., Gill AB., Kaggie JD., Grist JT., Crawford R., Latimer J., Baldwin P., Earl HM., Parkinson CA., Smith SA., Hodgkin C., Moore E., Jimenez-Linan M., Brodie CR., Addley HC., Freeman SJ., Moyle PL., Sala E., Graves MJ., Brenton JD., Gallagher FA.
The aim of this study was to assess the feasibility of rapid sodium MRI (23Na-MRI) for the imaging of peritoneal cancer deposits in high grade serous ovarian cancer (HGSOC) and to evaluate the relationship of 23Na-MRI with tumour cellularity. 23Na-MRI was performed at 3 T on twelve HGSOC patients using a 3D-cones acquisition technique. Tumour biopsies specimens were collected after imaging and cellularity was measured from histology. Total 23Na-MRI scan time for each patient was approximately 11 min. At an isotropic resolution of 5.6 mm, signal-to-noise ratios (SNRs) of 82.2 ± 15.3 and 15.1 ± 7.1 (mean ± standard deviation) were achieved for imaging of tumour tissue sodium concentration (TSC) and intracellular weighted sodium concentration (IWS) respectively. Tumour TSC and IWS concentrations were: 56.8 ± 19.1 mM and 30.8 ± 9.2 mM respectively and skeletal muscle TSC and IWS concentrations were 33.2 ± 16.3 mM and 20.5 ± 9.9 mM respectively. There were significant sodium concentration differences between cancer and skeletal muscle, Wilcoxon signed-rank test, P