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Cells are inherently sensitive to local mesoscale, microscale, and nanoscale patterns of chemistry and topography. We review current approaches to control cell behavior through the nanoscale engineering of materials surfaces. Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration.

Original publication

DOI

10.1126/science.1106587

Type

Journal article

Journal

Science

Publication Date

18/11/2005

Volume

310

Pages

1135 - 1138

Keywords

Animals, Biocompatible Materials, Cell Membrane, Cell Physiological Phenomena, Extracellular Matrix, Forecasting, Humans, Nanotechnology, Surface Properties, Tissue Engineering