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Rats were chronically implanted with stimulating electrodes in one caudate nucleus. Under light anaesthesia they received daily electrical stimulation (100-400 microA/HZ) for 30 min on 4 consecutive days. During this period, and for up to 3 subsequent days, tests for possible circling behaviour in response to administration of apomorphine i.p. were performed daily. Turning occurred towards the treated side and was reversible. The possibility is discussed that high levels of dopamine are released into the striatum during electrical stimulation, inducing transient subsensitivity of striatal dopamine receptors.

Type

Journal article

Journal

Neurosci Lett

Publication Date

18/05/1984

Volume

46

Pages

297 - 303

Keywords

Animals, Caudate Nucleus, Electric Stimulation, Functional Laterality, Male, Motor Activity, Rats, Rats, Inbred Strains, Rotation, Wakefulness