Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

AIMS/HYPOTHESIS: Hypomagnesaemia (blood Mg2+ <0.7 mmol/l) is a common phenomenon in individuals with type 2 diabetes. However, it remains unknown how a low blood Mg2+ concentration affects lipid and energy metabolism. Therefore, the importance of Mg2+ in obesity and type 2 diabetes has been largely neglected to date. This study aims to determine the effects of hypomagnesaemia on energy homeostasis and lipid metabolism. METHODS: Mice (n = 12/group) were fed either a low-fat diet (LFD) or a high-fat diet (HFD) (10% or 60% of total energy) in combination with a normal- or low-Mg2+ content (0.21% or 0.03% wt/wt) for 17 weeks. Metabolic cages were used to investigate food intake, energy expenditure and respiration. Blood and tissues were taken to study metabolic parameters and mRNA expression profiles, respectively. RESULTS: We show that low dietary Mg2+ intake ameliorates HFD-induced obesity in mice (47.00 ± 1.53 g vs 38.62 ± 1.51 g in mice given a normal Mg2+-HFD and low Mg2+-HFD, respectively, p 

Original publication

DOI

10.1007/s00125-018-4680-5

Type

Journal article

Journal

Diabetologia

Publication Date

09/2018

Volume

61

Pages

2030 - 2042

Keywords

Brown adipose tissue, Energy homeostasis, Hypomagnesaemia, Lipid metabolism, Lipolysis, Magnesium, Obesity, White adipose tissue, β-Adrenergic receptor, 3T3-L1 Cells, Animals, Diet, High-Fat, Insulin Resistance, Lipid Metabolism, Magnesium, Magnesium Deficiency, Male, Mice, Mice, Inbred C57BL, Obesity, Real-Time Polymerase Chain Reaction