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Several studies have demonstrated that electrical activation of the peripheral vestibular system can evoke field potential, multi-unit neuronal activity and acetylcholine release in the hippocampus (HPC). However, no study to date has employed the immediate early gene protein, c-Fos, to investigate the distribution of activation of cells in the HPC following electrical stimulation of the vestibular system. We found that vestibular stimulation increased the number of animals expressing c-Fos in the dorsal HPC compared to sham control rats (P ≤ 0.02), but not in the ventral HPC. c-Fos was also expressed in an increased number of animals in the dorsal dentate gyrus (DG) compared to sham control rats (P ≤ 0.0001), and to a lesser extent in the ventral DG (P ≤ 0.006). The results of this study show that activation of the vestibular system results in a differential increase in the expression of c-Fos across different regions of the HPC.

Original publication

DOI

10.1016/j.neulet.2018.04.041

Type

Journal article

Journal

Neurosci Lett

Publication Date

11/06/2018

Volume

677

Pages

60 - 64

Keywords

Electrical stimulation, Hippocampus, Vestibular system, c-Fos, Animals, Electric Stimulation, Hippocampus, Neural Pathways, Neurons, Proto-Oncogene Proteins c-fos, Rats, Wistar, Vestibule, Labyrinth