Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

CTP synthase (CTPS) can aggregate into an intracellular macrostructure, the cytoophidium, in various organisms including human cells. Previous studies have shown that assembly of human CTPS cytoophidia may be correlated with the cellular metabolic status, and is able to promote the activity of CTPS. A correlation between the cytoophidium and cancer metabolism has been proposed but not yet been revealed. In the current study we provide clear evidence of the presence of CTPS cytoophidia in various human cancers and some non-cancerous tissues. Moreover, among 203 tissue samples of hepatocellular carcinoma, 56 (28%) samples exhibited many cytoophidia, whereas no cytoophidia were detected in adjacent non-cancerous hepatocytes for all samples. Our findings suggest that the CTPS cytoophidium may participate in the adaptive metabolism of human hepatocellular carcinoma.

Original publication




Journal article


Exp Cell Res

Publication Date





292 - 299


CTP synthase, Cytoophidium, Glutamine metabolism, Heatshock protein 90, Human hepatocellular carcinoma, Nucleotide, Protein filamentation, Pyrimidine, Aged, Carbon-Nitrogen Ligases, Carcinoma, Hepatocellular, Cell Line, Tumor, Female, Gene Expression, HSP90 Heat-Shock Proteins, Hepatocytes, Humans, Liver Neoplasms, Male, Middle Aged, Neoplasm Proteins, Protein Aggregates