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<jats:title>Abstract</jats:title><jats:p>Mather and colleagues' arguments require rethinking at the mechanistic level. The arguments on the physiological effects of norepinephrine at the cortical level are inconsistent with large parts of the literature. There is no evidence that norepinephrine induces local “hotspots”: Norepinephrine mainly decreases evoked responses; facilitating effects are rare and not localized. More generally, the idea that perception benefits from “local hotspots” is hardly compatible with the fact that neural representations involve largely distributed activation of cortical and subcortical networks.</jats:p>

Original publication

DOI

10.1017/s0140525x1500179x

Type

Journal article

Journal

Behavioral and Brain Sciences

Publisher

Cambridge University Press (CUP)

Publication Date

2016

Volume

39