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The transcription factors that regulate endothelial cell development have been a focus of active research for several years, and many players in the endothelial transcriptional program have been identified. This review discusses the function of several major regulators of endothelial transcription, including members of the Sox, Ets, Forkhead, GATA, and Kruppel-like families. This review also highlights recent developments aimed at unraveling the combinatorial mechanisms and transcription factor interactions that regulate endothelial cell specification and differentiation during vasculogenesis and angiogenesis.

Original publication

DOI

10.1016/j.devcel.2009.01.014

Type

Journal article

Journal

Dev Cell

Publication Date

02/2009

Volume

16

Pages

180 - 195

Keywords

Animals, Cell Differentiation, Cell Proliferation, Endothelial Cells, Endothelium, Vascular, Hematopoietic Stem Cells, Humans, Mesoderm, Mice, Models, Biological, Neovascularization, Pathologic, Stem Cells, Transcription Factors, Transcription, Genetic, Zebrafish