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INTRODUCTION: Changes in personality have been described in Parkinson's disease (PD), with suggestion that those with established disease tend to be risk averse with a disinclination for addictive behaviour. However, little is known about the earliest and prodromal stages. Personality and its relationship with addictive behaviours can help answer important questions about the mechanisms underlying PD and addiction. METHODS: 941 population-ascertained PD subjects within 3.5 years of diagnosis, 128 patients with rapid eye movement sleep behaviour disorder (RBD) and 292 control subjects were fully characterised for motor symptoms, non-motor symptoms and across the following 5 personality domains: 1) neuroticism 2) extraversion 3) conscientiousness 4) agreeableness 5) openness using the Big Five Inventory. RESULTS: Patients with early PD were more neurotic (p 

Original publication




Journal article


Parkinsonism Relat Disord

Publication Date





72 - 78


Addiction, Parkinson's disease, Personality, REM sleep behaviour disorder, Smoking, Adult, Aged, Aged, 80 and over, Behavior, Addictive, Female, Humans, Male, Middle Aged, Parkinson Disease, Personality, Personality Assessment, Personality Disorders, REM Sleep Behavior Disorder, Severity of Illness Index