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When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.

Original publication




Journal article


J Cardiovasc Transl Res

Publication Date





405 - 418


Cardiac stem cells, Heart disease, Regenerative medicine, Stem cell therapy, Animals, Cell Differentiation, Cell Proliferation, Cell Survival, Clinical Trials as Topic, Heart Diseases, Humans, Myocytes, Cardiac, Phenotype, Recovery of Function, Regeneration, Regenerative Medicine, Signal Transduction, Stem Cell Transplantation, Translational Medical Research