The epithelial cells of the lung are at the interface of a host and its environment and are therefore directly exposed to the inhaled air-borne particles. Rather than serving as a simple physical barrier, airway epithelia detect allergens and other irritants and then help organize the subsequent immune response through release of a plethora of secreted signals. Many of these signals are generated in response to opening of store-operated Ca(2+) channels in the plasma membrane. In this review, we describe the properties of airway store-operated channels and their role in regulating airway epithelial cell function.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.

Original publication

DOI

10.1098/rstb.2015.0424

Type

Journal article

Journal

Philos Trans R Soc Lond B Biol Sci

Publication Date

05/08/2016

Volume

371

Keywords

Ca2+ signalling, airway epithelia, store-operated Ca2+ channel, Calcium, Calcium Channels, Calcium Signaling, Epithelial Cells, Humans, Lung