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Achromobacter spp. are emerging pathogens in the lungs of patients with cystic fibrosis. We report the case of an adult patient with cystic fibrosis and chronic A. xylosoxidans infection who experienced rapid, progressive clinical deterioration. Metagenomic analysis of the sputum revealed that the airway microbiota was almost entirely dominated by A. xylosoxidans. We review the impact of this organism on lung function and the airway microbiome in cystic fibrosis, and discuss the potential for cross-infection between patients.

Original publication

DOI

10.1016/j.prrv.2016.06.011

Type

Journal article

Journal

Paediatr Respir Rev

Publication Date

08/2016

Volume

20 Suppl

Pages

27 - 29

Keywords

Achromobacter xylosoxidans, Cross-infection, Cystic fibrosis, Sputum microbiome, Achromobacter denitrificans, Adult, Anti-Bacterial Agents, Cross Infection, Cystic Fibrosis, Gram-Negative Bacterial Infections, Humans, Lung Transplantation, Male, Sputum