Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Regenerative medicine using mesenchymal stem cells for the purposes of tissue repair has garnered considerable public attention due to the potential of returning tissues and organs to a normal, healthy state after injury or damage has occurred. To achieve this, progenitor cells such as pericytes and bone marrow-derived mesenchymal stem cells can be delivered exogenously, mobilised and recruited from within the body or transplanted in the form organs and tissues grown in the laboratory from stem cells. In this review, we summarise the recent evidence supporting the use of endogenously mobilised stem cell populations to enhance tissue repair along with the use of mesenchymal stem cells and pericytes in the development of engineered tissues. Finally, we conclude with an overview of currently available therapeutic options to manipulate endogenous stem cells to promote tissue repair.

Original publication




Journal article


Pharmacol Ther

Publication Date





107 - 120


Fibrosis, Mesenchymal stem cell, Pericyte, Regenerative medicine, Tissue engineering, Tissue repair, Animals, Cell Movement, Fibrosis, Humans, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Neovascularization, Physiologic, Pericytes, Regeneration, Tissue Engineering