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A novel method (Sophia) is presented to track oxygen saturation changes in a controlled environment using an RGB camera placed approximately 1.5 m away from the subject. The method is evaluated on five healthy volunteers (Fitzpatrick skin phenotypes II, III, and IV) whose oxygen saturations were varied between 80% and 100% in a purpose-built chamber over 40 minutes each. The method carefully selects regions of interest (ROI) in the camera image by calculating signal-to-noise ratios for each ROI. This allows it to track changes in oxygen saturation accurately with respect to a conventional pulse oximeter (median coefficient of determination, 0.85).

Original publication




Journal article


Biomed Opt Express

Publication Date





3320 - 3338


(170.0110) Imaging systems, (170.0170) Medical optics and biotechnology, (170.1460) Blood gas monitoring, (170.1470) Blood or tissue constituent monitoring, (170.3660) Light propagation in tissues, (280.0280) Remote sensing and sensors