Lineage analysis in the vertebrate central nervous system
Cepko CL., Golden JA., Szele FG., Lin JC.
© 1997 by Oxford University Press. All rights reserved.This chapter focuses on lineage analysis in the vertebrate nervous system. It begins with the definition of lineal analysis followed by a discussion of methods of lineage analysis. It then presents examples of lineage analysis conducted in the vertebrate central nervous system (CNS). Lineage analysis of the retina has shown that retinal progenitors are multipotent, most likely through the final cell division; the pattern of cell divisions can be symmetric or asymmetric with respect to the mitotic behavior of daughter cells; and postmitotic retinal cells migrate radially with relatively little tangential migration.