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© 2012 Springer-Verlag/Wien. All rights reserved. It is now universally appreciated that cytoplasmic Ca2+ is a versatile messenger, capable of eliciting a wide range of cellular responses spread throughout the time domain (Clapham 2008). One of the more remarkable consequences of a Ca2+ rise is its ability to influence events in the nucleus, long after the Ca2+ signal has disappeared (Berridge et al. 2003). A pulse of Ca2+ for a few seconds is often enough to promote translocation of cytoplasmic Ca2+-dependent transcription factors like CREB or NFAT into the nucleus, resulting in gene expression. Ca2+-dependent gene expression plays a very important role in numerous distinct organ systems including learning and memory in the brain, cardiac remodeling and development and function of the immune system.

Original publication





Book title

Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology

Publication Date





133 - 135