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Despite the role of chloride channels and anion/proton antiporters of the CLC protein family in physiological processes and different genetic diseases, their pharmacology has been under-developed. In this issue of Chemistry & Biology, Howery et al. report the synthesis of 4'-octanamidostilbene-2,2'-disulfonate, the first high-affinity inhibitor of a CLC antiporter, a critical step toward reviving the CLC pharmacology.

Original publication

DOI

10.1016/j.chembiol.2012.10.009

Type

Journal article

Journal

Chem Biol

Publication Date

21/11/2012

Volume

19

Pages

1358 - 1359