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© 2014 by John Wiley & Sons, Inc. All rights reserved. Alterations in the synthesis and degradation of cAMP and cGMP have potent effects on the membrane activity of neurons recorded in numerous regions of the CNS. This chapter reviews the literature on cyclic nucleotide signaling and neuron activity in major brain regions, including the cortex, hippocampus, and striatum. The impact of nonselective and selective PDE inhibitors on membrane activity and synaptic plasticity will be summarized. Finally, this chapter discusses the implications of the effects PDE modulation on electrophysiological activity of central neurons as it pertains to the treatment of neurological disorders.

Original publication





Book title

Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery

Publication Date



269 - 302