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This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.

Original publication

DOI

10.1016/j.pbiomolbio.2014.07.010

Type

Journal article

Journal

Prog Biophys Mol Biol

Publication Date

08/2014

Volume

115

Pages

115 - 128

Keywords

Cardiac mechano-electric coupling, Cardiac tissue, Cardiomyocyte interaction, Electro-mechanical mathematical model, Excitation-contraction coupling, Mechano-electric feedback, Animals, Excitation Contraction Coupling, Heart Conduction System, Models, Biological, Myocardial Contraction, Ventricular Function