The cardiac muscle duplex as a method to study myocardial heterogeneity.
Solovyova O., Katsnelson LB., Konovalov PV., Kursanov AG., Vikulova NA., Kohl P., Markhasin VS.
This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.