Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.

Original publication




Journal article


Prog Biophys Mol Biol

Publication Date





115 - 128


Cardiac mechano-electric coupling, Cardiac tissue, Cardiomyocyte interaction, Electro-mechanical mathematical model, Excitation-contraction coupling, Mechano-electric feedback, Animals, Excitation Contraction Coupling, Heart Conduction System, Models, Biological, Myocardial Contraction, Ventricular Function