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The subplate layer, the deepest cortical layer in mammals, has important roles in cerebral cortical development. The subplate contains heterogeneous cell populations that are morphologically diverse, with several projection targets. It is currently assumed that these cells are generated in the germinative zone of the earliest cortical neuroepithelium. Here we identify a pallial but extracortical area located in the rostromedial telencephalic wall (RMTW) that gives rise to several cell populations. Postmitotic neurons migrate tangentially from the RMTW toward the cerebral cortex. Most RMTW-derived cells are incorporated into the subplate layer throughout its rostrocaudal extension, with others contributing to the GABAergic interneuron pool of cortical layers V and VI.

Original publication




Journal article


Proc Natl Acad Sci U S A

Publication Date





8613 - 8618


cell migration, pallium, preplate, projecting cells, Animals, Cell Movement, Cerebral Cortex, Embryo, Mammalian, GABAergic Neurons, Green Fluorescent Proteins, Interneurons, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Confocal, Microscopy, Fluorescence, Neurons, Time Factors, gamma-Aminobutyric Acid