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Neurogenesis has been the subject of active research in recent years. Although the majority of neurons form during the embryonic period, neurogenesis continues in restricted regions of the mammalian brain well into adulthood. In rodent brains, neuronal migration is present in the rostral migratory stream (RMS), connecting the subventricular zone to the olfactory bulb (OB). The migration in the RMS is characterised by a lack of dispersion of neuroblasts into the surrounding tissues and a highly directed motion towards the OB. This study uses a simple mathematical model to investigate several theories of migration of neuroblasts through the RMS proposed in the literature, including chemo-attraction, chemorepulsion, general inhibition and the presence of a migration-inducing protein. Apart from the general inhibition model, all the models were able to provide results in good qualitative correspondence with the experimental observations.

Original publication

DOI

10.1080/10255842.2013.773979

Type

Journal article

Journal

Comput Methods Biomech Biomed Engin

Publication Date

10/2013

Volume

16

Pages

1096 - 1105

Keywords

Animals, Brain, Cell Movement, Models, Neurological, Neural Stem Cells, Neurogenesis, Olfactory Bulb