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Gating deficits and hallucinatory sensations are prominent symptoms of schizophrenia. Comparing these abnormalities with the failure modes of network models is an interesting way to explore how they arise. We present a network model that can both propagate and gate signals. The model exhibits effects reminiscent of clinically observed pathologies when the balance between excitation and inhibition that it requires is not properly maintained.

Original publication

DOI

10.1055/s-2007-992130

Type

Journal article

Journal

Pharmacopsychiatry

Publication Date

12/2007

Volume

40 Suppl 1

Pages

S73 - S77

Keywords

Brain, Humans, Models, Neurological, Neural Networks (Computer), Schizophrenia, Schizophrenic Psychology