Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO influences growth and body composition are unknown. We describe a role for FTO in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling. These findings suggest that FTO may influence body composition through playing a role in cellular nutrient sensing.

Original publication




Journal article


Proc Natl Acad Sci U S A

Publication Date





2557 - 2562


Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Amino Acids, Animals, Body Composition, Cell Fractionation, Chromatography, Liquid, Electrophoresis, Polyacrylamide Gel, Fibroblasts, HEK293 Cells, Humans, Immunoprecipitation, Mice, Obesity, Polymorphism, Single Nucleotide, Proteins, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, TOR Serine-Threonine Kinases, Tandem Mass Spectrometry