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Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.

Original publication

DOI

10.1093/nar/gks1323

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

01/02/2013

Volume

41

Keywords

Animals, Base Sequence, Consensus Sequence, DNA, Drosophila melanogaster, Gene Library, Gene Regulatory Networks, Microfluidic Analytical Techniques, Nucleotide Motifs, Position-Specific Scoring Matrices, Regulatory Elements, Transcriptional, Transcription Factors