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The presence of angiotensin converting enzyme (ACE) in insects has been reported many times, but numerous questions about the functional role of this enzyme in insects remain. Here we show by RT-PCR experiments that ACE has a wide tissue distribution in Locusta migratoria, suggesting diverse roles for this enzyme in the locust. Immune challenge through injection of bacterial lipopolysaccharides resulted in a tenfold increase of ACE gene transcripts in the hemocytes and is suggestive for a role of ACE in the cellular defense of the locust. However, phenotypic knockout experiments with the ACE inhibitor captopril showed that ACE is not essential for the efficient clearance of injected E. coli bacteria.

Type

Journal article

Journal

J Insect Physiol

Publication Date

08/2003

Volume

49

Pages

739 - 746

Keywords

Amino Acid Sequence, Angiotensin-Converting Enzyme Inhibitors, Animals, Captopril, Escherichia coli, Grasshoppers, Hemocytes, Lipopolysaccharides, Molecular Sequence Data, RNA, Messenger, Renin, Reverse Transcriptase Polymerase Chain Reaction, Sequence Alignment, Transcription, Genetic